Use of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells

Claudins regulate paracellular permeability in different tissues. The claudin-binding domain of Clostridium perfringens enterotoxin (cCPE) is a known modulator of a claudin subset. However, it does not efficiently bind to claudin-1 (Cldn1). Cldn1 is a pharmacological target since it is (i) an essent...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Beier, Laura-Sophie, Rossa, Jan, Woodhouse, Stephen, Bergmann, Sophia, Kramer, Holger B., Protze, Jonas, Eichner, Miriam, Piontek, Anna, Vidal-y-Sy, Sabine, Brandner, Johanna M., Krause, Gerd, Zitzmann, Nicole, Piontek, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801472/
https://ncbi.nlm.nih.gov/pubmed/31561440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20194774
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