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Mechanism of Clostridium perfringens Enterotoxin Interaction with Claudin-3/-4 Protein Suggests Structural Modifications of the Toxin to Target Specific Claudins

Claudins (Cld) are essential constituents of tight junctions. Domain I of Clostridium perfringens enterotoxin (cCPE) binds to the second extracellular loop (ECL2) of a subset of claudins, e.g. Cld3/4 and influences tight junction formation. We aimed to identify interacting interfaces and to alter cl...

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Main Authors: Veshnyakova, Anna, Piontek, Jörg, Protze, Jonas, Waziri, Negar, Heise, Ivonne, Krause, Gerd
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265853/
https://ncbi.nlm.nih.gov/pubmed/22128179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.312165
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