A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus

Influenza A virus (IAV) causes significant morbidity and mortality, despite the availability of viral vaccines. The efficacy of live attenuated influenza vaccines (LAIVs) has been especially poor in recent years. One potential reason is that the master donor virus (MDV), on which all LAIVs are based...

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發表在:J Virol
Main Authors: Smith, Andrew, Rodriguez, Laura, El Ghouayel, Maya, Nogales, Aitor, Chamberlain, Jeffrey M., Sortino, Katherine, Reilly, Emma, Feng, Changyong, Topham, David J., Martínez-Sobrido, Luis, Dewhurst, Stephen
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2020
主題:
Vaccines and Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997774/
https://ncbi.nlm.nih.gov/pubmed/31748399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01065-19
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