A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus

Influenza A virus (IAV) causes significant morbidity and mortality, despite the availability of viral vaccines. The efficacy of live attenuated influenza vaccines (LAIVs) has been especially poor in recent years. One potential reason is that the master donor virus (MDV), on which all LAIVs are based...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Smith, Andrew, Rodriguez, Laura, El Ghouayel, Maya, Nogales, Aitor, Chamberlain, Jeffrey M., Sortino, Katherine, Reilly, Emma, Feng, Changyong, Topham, David J., Martínez-Sobrido, Luis, Dewhurst, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997774/
https://ncbi.nlm.nih.gov/pubmed/31748399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01065-19
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