A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus

Influenza A virus (IAV) causes significant morbidity and mortality, despite the availability of viral vaccines. The efficacy of live attenuated influenza vaccines (LAIVs) has been especially poor in recent years. One potential reason is that the master donor virus (MDV), on which all LAIVs are based...

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Veröffentlicht in:J Virol
Hauptverfasser: Smith, Andrew, Rodriguez, Laura, El Ghouayel, Maya, Nogales, Aitor, Chamberlain, Jeffrey M., Sortino, Katherine, Reilly, Emma, Feng, Changyong, Topham, David J., Martínez-Sobrido, Luis, Dewhurst, Stephen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997774/
https://ncbi.nlm.nih.gov/pubmed/31748399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01065-19
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