Alpha-synuclein fragments trigger distinct aggregation pathways

Aggregation of alpha-synuclein (αSyn) is a crucial event underlying the pathophysiology of synucleinopathies. The existence of various intracellular and extracellular αSyn species, including cleaved αSyn, complicates the quest for an appropriate therapeutic target. Hence, to develop efficient diseas...

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Bibliografiska uppgifter
I publikationen:Cell Death Dis
Huvudupphovsmän: Chakroun, Tasnim, Evsyukov, Valentin, Nykänen, Niko-Petteri, Höllerhage, Matthias, Schmidt, Andreas, Kamp, Frits, Ruf, Viktoria C., Wurst, Wolfgang, Rösler, Thomas W., Höglinger, Günter U.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997403/
https://ncbi.nlm.nih.gov/pubmed/32015326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2285-7
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