Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy

Accumulation of pathological α-synuclein aggregates plays a major role in Parkinson’s disease. Macroautophagy is a mechanism to degrade intracellular protein aggregates by wrapping them into autophagosomes, followed by fusion with lysosomes. We had previously shown that pharmacological activation of...

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Udgivet i:Cell Death Dis
Main Authors: Fussi, Natascha, Höllerhage, Matthias, Chakroun, Tasnim, Nykänen, Niko-Petteri, Rösler, Thomas W., Koeglsperger, Thomas, Wurst, Wolfgang, Behrends, Christian, Höglinger, Günter U.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037700/
https://ncbi.nlm.nih.gov/pubmed/29988147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0816-2
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