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Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy
Accumulation of pathological α-synuclein aggregates plays a major role in Parkinson’s disease. Macroautophagy is a mechanism to degrade intracellular protein aggregates by wrapping them into autophagosomes, followed by fusion with lysosomes. We had previously shown that pharmacological activation of...
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| Veröffentlicht in: | Cell Death Dis |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6037700/ https://ncbi.nlm.nih.gov/pubmed/29988147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0816-2 |
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