Alpha-synuclein fragments trigger distinct aggregation pathways

Aggregation of alpha-synuclein (αSyn) is a crucial event underlying the pathophysiology of synucleinopathies. The existence of various intracellular and extracellular αSyn species, including cleaved αSyn, complicates the quest for an appropriate therapeutic target. Hence, to develop efficient diseas...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Chakroun, Tasnim, Evsyukov, Valentin, Nykänen, Niko-Petteri, Höllerhage, Matthias, Schmidt, Andreas, Kamp, Frits, Ruf, Viktoria C., Wurst, Wolfgang, Rösler, Thomas W., Höglinger, Günter U.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997403/
https://ncbi.nlm.nih.gov/pubmed/32015326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2285-7
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