Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy

Accumulation of pathological α-synuclein aggregates plays a major role in Parkinson’s disease. Macroautophagy is a mechanism to degrade intracellular protein aggregates by wrapping them into autophagosomes, followed by fusion with lysosomes. We had previously shown that pharmacological activation of...

Full description

Saved in:
Bibliographic Details
Published in:Cell Death Dis
Main Authors: Fussi, Natascha, Höllerhage, Matthias, Chakroun, Tasnim, Nykänen, Niko-Petteri, Rösler, Thomas W., Koeglsperger, Thomas, Wurst, Wolfgang, Behrends, Christian, Höglinger, Günter U.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037700/
https://ncbi.nlm.nih.gov/pubmed/29988147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0816-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items