Maf1‐dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan

Maf1 is the master repressor of RNA polymerase III responsible for transcription of tRNAs and 5S rRNAs. Maf1 is negatively regulated via phosphorylation by the mTOR pathway, which governs protein synthesis, growth control, and lifespan regulation in response to nutrient availability. Inhibiting the...

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發表在:Aging Cell
Main Authors: Shetty, Mihir, Noguchi, Chiaki, Wilson, Sydney, Martinez, Esteban, Shiozaki, Kazuhiro, Sell, Christian, Mell, Joshua Chang, Noguchi, Eishi
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2019
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996946/
https://ncbi.nlm.nih.gov/pubmed/31833215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13068
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