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Maf1‐dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan
Maf1 is the master repressor of RNA polymerase III responsible for transcription of tRNAs and 5S rRNAs. Maf1 is negatively regulated via phosphorylation by the mTOR pathway, which governs protein synthesis, growth control, and lifespan regulation in response to nutrient availability. Inhibiting the...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6996946/ https://ncbi.nlm.nih.gov/pubmed/31833215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13068 |
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