Maf1 limits RNA polymerase III-directed transcription to preserve genomic integrity and extend lifespan

A key to longevity assurance is the nutrient-sensing mTOR pathway. Inhibition of mTOR extends lifespan in a variety of organisms. However, the downstream effectors of the mTOR pathway for lifespan regulation are elusive. In a recent report, we described the role of Maf1 as a critical lifespan regula...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Noguchi, Chiaki, Wang, Lucy, Shetty, Mihir, Mell, Joshua Chang, Sell, Christian, Noguchi, Eishi
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2021
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7889123/
https://ncbi.nlm.nih.gov/pubmed/33475456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2021.1874697
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