Protein arginine methyltransferase 5 represses tumor suppressor miRNAs that down-regulate CYCLIN D1 and c-MYC expression in aggressive B-cell lymphoma

Protein arginine methyltransferase-5 (PRMT5) is overexpressed in aggressive B-cell non-Hodgkin's lymphomas, including mantle cell lymphoma and diffuse large B-cell lymphoma, and supports constitutive expression of CYCLIN D1 and c-MYC. Here, we combined ChIP analysis with next-generation sequenc...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Karkhanis, Vrajesh, Alinari, Lapo, Ozer, Hatice Gulcin, Chung, Jihyun, Zhang, Xiaoli, Sif, Saïd, Baiocchi, Robert A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
Matèries:
Gene Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996892/
https://ncbi.nlm.nih.gov/pubmed/31822509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008742
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