Protein Arginine Methyltransferase 5 (PRMT5) Inhibition Induces Lymphoma Cell Death through Reactivation of the Retinoblastoma Tumor Suppressor Pathway and Polycomb Repressor Complex 2 (PRC2) Silencing

Epigenetic regulation mediated by lysine- and arginine-specific enzymes plays an essential role in tumorigenesis, and enhanced expression of the type II protein arginine methyltransferase PRMT5 as well as the polycomb repressor complex PRC2 has been associated with increased cell proliferation and s...

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Detalhes bibliográficos
Main Authors: Chung, Jihyun, Karkhanis, Vrajesh, Tae, Sookil, Yan, Fengting, Smith, Porsha, Ayers, Leona W., Agostinelli, Claudio, Pileri, Stefano, Denis, Gerald V., Baiocchi, Robert A., Sif, Saïd
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853299/
https://ncbi.nlm.nih.gov/pubmed/24189068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510669
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