Protein Arginine Methyltransferase 5 (PRMT5) Inhibition Induces Lymphoma Cell Death through Reactivation of the Retinoblastoma Tumor Suppressor Pathway and Polycomb Repressor Complex 2 (PRC2) Silencing

Epigenetic regulation mediated by lysine- and arginine-specific enzymes plays an essential role in tumorigenesis, and enhanced expression of the type II protein arginine methyltransferase PRMT5 as well as the polycomb repressor complex PRC2 has been associated with increased cell proliferation and s...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Chung, Jihyun, Karkhanis, Vrajesh, Tae, Sookil, Yan, Fengting, Smith, Porsha, Ayers, Leona W., Agostinelli, Claudio, Pileri, Stefano, Denis, Gerald V., Baiocchi, Robert A., Sif, Saïd
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2013
الموضوعات:
Molecular Bases of Disease
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853299/
https://ncbi.nlm.nih.gov/pubmed/24189068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510669
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