Protein Arginine Methyltransferase 5 (PRMT5) Inhibition Induces Lymphoma Cell Death through Reactivation of the Retinoblastoma Tumor Suppressor Pathway and Polycomb Repressor Complex 2 (PRC2) Silencing

Epigenetic regulation mediated by lysine- and arginine-specific enzymes plays an essential role in tumorigenesis, and enhanced expression of the type II protein arginine methyltransferase PRMT5 as well as the polycomb repressor complex PRC2 has been associated with increased cell proliferation and s...

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Bibliografski detalji
Glavni autori: Chung, Jihyun, Karkhanis, Vrajesh, Tae, Sookil, Yan, Fengting, Smith, Porsha, Ayers, Leona W., Agostinelli, Claudio, Pileri, Stefano, Denis, Gerald V., Baiocchi, Robert A., Sif, Saïd
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Molecular Bases of Disease
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853299/
https://ncbi.nlm.nih.gov/pubmed/24189068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510669
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