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MCUB regulates the molecular composition of the mitochondrial calcium uniporter channel to limit mitochondrial calcium overload during stress
BACKGROUND: The mitochondrial calcium uniporter (mtCU) is a ~700 kD multi-subunit channel residing in the inner mitochondrial membrane (IMM) required for mitochondrial Ca(2+) ((m)Ca(2+)) uptake. Here we detail the contribution of MCUB, a paralog of the pore-forming subunit - MCU, in mtCU regulation...
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| Pubblicato in: | Circulation |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6996560/ https://ncbi.nlm.nih.gov/pubmed/31533452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.037968 |
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