Drysdalin, an antagonist of nicotinic acetylcholine receptors highlights the importance of functional rather than structural conservation of amino acid residues

Snake venom neurotoxins are potent antagonists of nicotinic acetylcholine receptors (nAChRs). Here, we describe a novel member of class 3c long‐chain neurotoxin drysdalin from the venom of Drysdalia coronoides. Drysdalin lacks three of the eight conserved classical functional residues critical for n...

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Udgivet i:FASEB Bioadv
Main Authors: Chandna, Ritu, Tae, Han‐Shen, Seymour, Victoria A. L., Chathrath, Shifali, Adams, David J., Kini, R. Manjunatha
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996315/
https://ncbi.nlm.nih.gov/pubmed/32123825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fba.1027
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