Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors

[Image: see text] Conformational restriction of the pyrrolidine nitrogen in nicotine by the introduction of an ethylene bridge provided a potent and selective antagonist of the α4β2-subtype of the nicotinic acetylcholine receptors. Resolution by chiral SFC, pharmacological characterization of the tw...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Petersen, Ida Nymann, Crestey, François, Jensen, Anders A., Indurthi, Dinesh C., Pedersen, Henrik, Andreasen, Jesper T., Balle, Thomas, Kristensen, Jesper L.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2015
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416435/
https://ncbi.nlm.nih.gov/pubmed/25941557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00028
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