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Evolutionary Analyses of Sequence and Structure Space Unravel the Structural Facets of SOD1
Superoxide dismutase (SOD) is the primary enzyme of the cellular antioxidant defense cascade. Misfolding, concomitant oligomerization, and higher order aggregation of human cytosolic SOD are linked to amyotrophic lateral sclerosis (ALS). Although, with two metal ion cofactors SOD1 is extremely robus...
Guardat en:
| Publicat a: | Biomolecules |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6995586/ https://ncbi.nlm.nih.gov/pubmed/31817166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9120826 |
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