The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model

Aggregation of Cu–Zn superoxide dismutase (SOD1) is implicated in the motor neuron disease, amyotrophic lateral sclerosis (ALS). Although more than 140 disease mutations of SOD1 are available, their stability or aggregation behaviors in membrane environment are not correlated with disease pathophysi...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Sannigrahi, Achinta, Chowdhury, Sourav, Das, Bidisha, Banerjee, Amrita, Halder, Animesh, Kumar, Amaresh, Saleem, Mohammed, Naganathan, Athi N, Karmakar, Sanat, Chattopadhyay, Krishnananda
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2021
Konular:
Structural Biology and Molecular Biophysics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087447/
https://ncbi.nlm.nih.gov/pubmed/33825682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61453
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