Evolutionary Analyses of Sequence and Structure Space Unravel the Structural Facets of SOD1

Superoxide dismutase (SOD) is the primary enzyme of the cellular antioxidant defense cascade. Misfolding, concomitant oligomerization, and higher order aggregation of human cytosolic SOD are linked to amyotrophic lateral sclerosis (ALS). Although, with two metal ion cofactors SOD1 is extremely robus...

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Publicado en:Biomolecules
Main Authors: Chowdhury, Sourav, Sanyal, Dwipanjan, Sen, Sagnik, Uversky, Vladimir N., Maulik, Ujjwal, Chattopadhyay, Krishnananda
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995586/
https://ncbi.nlm.nih.gov/pubmed/31817166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9120826
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