Evolutionary Analyses of Sequence and Structure Space Unravel the Structural Facets of SOD1

Superoxide dismutase (SOD) is the primary enzyme of the cellular antioxidant defense cascade. Misfolding, concomitant oligomerization, and higher order aggregation of human cytosolic SOD are linked to amyotrophic lateral sclerosis (ALS). Although, with two metal ion cofactors SOD1 is extremely robus...

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Vydáno v:Biomolecules
Hlavní autoři: Chowdhury, Sourav, Sanyal, Dwipanjan, Sen, Sagnik, Uversky, Vladimir N., Maulik, Ujjwal, Chattopadhyay, Krishnananda
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995586/
https://ncbi.nlm.nih.gov/pubmed/31817166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9120826
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