The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model

Aggregation of Cu–Zn superoxide dismutase (SOD1) is implicated in the motor neuron disease, amyotrophic lateral sclerosis (ALS). Although more than 140 disease mutations of SOD1 are available, their stability or aggregation behaviors in membrane environment are not correlated with disease pathophysi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Sannigrahi, Achinta, Chowdhury, Sourav, Das, Bidisha, Banerjee, Amrita, Halder, Animesh, Kumar, Amaresh, Saleem, Mohammed, Naganathan, Athi N, Karmakar, Sanat, Chattopadhyay, Krishnananda
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087447/
https://ncbi.nlm.nih.gov/pubmed/33825682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61453
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