A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcripts with elusive functions in metabolism. Here we show that a high fraction of lncRNAs, but not protein-coding mRNAs, are repressed during diet-induced obesity (DIO) and refeeding, wh...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Nat Commun
المؤلفون الرئيسيون: Pradas-Juni, Marta, Hansmeier, Nils R., Link, Jenny C., Schmidt, Elena, Larsen, Bjørk Ditlev, Klemm, Paul, Meola, Nicola, Topel, Hande, Loureiro, Rute, Dhaouadi, Ines, Kiefer, Christoph A., Schwarzer, Robin, Khani, Sajjad, Oliverio, Matteo, Awazawa, Motoharu, Frommolt, Peter, Heeren, Joerg, Scheja, Ludger, Heine, Markus, Dieterich, Christoph, Büning, Hildegard, Yang, Ling, Cao, Haiming, Jesus, Dario F. De, Kulkarni, Rohit N., Zevnik, Branko, Tröder, Simon E., Knippschild, Uwe, Edwards, Peter A., Lee, Richard G., Yamamoto, Masayuki, Ulitsky, Igor, Fernandez-Rebollo, Eduardo, Vallim, Thomas Q. de Aguiar, Kornfeld, Jan-Wilhelm
التنسيق: Artigo
اللغة:Inglês
منشور في: Nature Publishing Group UK 2020
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994702/
https://ncbi.nlm.nih.gov/pubmed/32005828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14323-y
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