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Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells
We have previously reported that transient knock-down of ATPase inhibitory factor 1 (IF1) by siRNA upregulates ATP levels and subsequently augments insulin secretion in model pancreatic β-cells INS-1E. Here we investigated how long-term IF1-overexpression impacts pancreatic β-cell bioenergetics and...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6994519/ https://ncbi.nlm.nih.gov/pubmed/32005857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58411-x |
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