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Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells

We have previously reported that transient knock-down of ATPase inhibitory factor 1 (IF1) by siRNA upregulates ATP levels and subsequently augments insulin secretion in model pancreatic β-cells INS-1E. Here we investigated how long-term IF1-overexpression impacts pancreatic β-cell bioenergetics and...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Kahancová, Anežka, Sklenář, Filip, Ježek, Petr, Dlasková, Andrea
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994519/
https://ncbi.nlm.nih.gov/pubmed/32005857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58411-x
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