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Genetic deficiency of IFNγ reveals IFNγ-independent manifestations of murine Hemophagocytic Lymphohistiocytosis
OBJECTIVE: Familial hemophagocytic lymphohistiocytosis (FHL) is a complex cytokine storm syndrome caused by genetic abnormalities rendering CD8+ T cells and NK cells incapable of cytolytic killing. Murine models of FHL have identified interferon-gamma (IFNγ) made by CD8+ T cells as a critical mediat...
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| Publicado no: | Arthritis Rheumatol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6994338/ https://ncbi.nlm.nih.gov/pubmed/31400073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41076 |
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