Disruption of IL-33 Signaling Limits Early CD8+ T Cell Effector Function Leading to Exhaustion in Murine Hemophagocytic Lymphohistiocytosis

Danger signals mediated through ST2, the interleukin-33 (IL-33) receptor, amplify CD8(+) T cell-mediated inflammation in the murine model of familial hemophagocytic lymphohistiocytosis type 2 (FHL2), and blockade of ST2 provides a potential therapeutic strategy in this disease. However, the long-ter...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Rood, Julia E., Burn, Thomas N., Neal, Vanessa, Chu, Niansheng, Behrens, Edward M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256032/
https://ncbi.nlm.nih.gov/pubmed/30515155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02642
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