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Disruption of IL-33 Signaling Limits Early CD8+ T Cell Effector Function Leading to Exhaustion in Murine Hemophagocytic Lymphohistiocytosis
Danger signals mediated through ST2, the interleukin-33 (IL-33) receptor, amplify CD8(+) T cell-mediated inflammation in the murine model of familial hemophagocytic lymphohistiocytosis type 2 (FHL2), and blockade of ST2 provides a potential therapeutic strategy in this disease. However, the long-ter...
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| Udgivet i: | Front Immunol |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6256032/ https://ncbi.nlm.nih.gov/pubmed/30515155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02642 |
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