GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein

Antigen receptor–dependent (AgR-dependent) stimulation of the NF-κB transcription factor in lymphocytes is a required event during adaptive immune response, but dysregulated activation of this signaling pathway can lead to lymphoma. AgR stimulation promotes assembly of the CARMA1-BCL10-MALT1 complex...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Cheng, Jing, Klei, Linda R., Hubel, Nathaniel E., Zhang, Ming, Schairer, Rebekka, Maurer, Lisa M., Klei, Hanna B., Kang, Heejae, Concel, Vincent J., Delekta, Phillip C., Dang, Eric V., Mintz, Michelle A., Baens, Mathijs, Cyster, Jason G., Parameswaran, Narayanan, Thome, Margot, Lucas, Peter C., McAllister-Lucas, Linda M.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994119/
https://ncbi.nlm.nih.gov/pubmed/31961340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97040
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