Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-κB activation

Proper regulation of nuclear factor-κB (NF-κB) transcriptional activity is required for normal lymphocyte function, and deregulated NF-κB signaling can facilitate lymphomagenesis. We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated ly...

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Hlavní autoři: Rosebeck, Shaun, Madden, Lisa, Jin, Xiaohong, Gu, Shufang, Apel, Ingrid J., Appert, Alex, Hamoudi, Rifat A., Noels, Heidi, Sagaert, Xavier, Van Loo, Peter, Baens, Mathijs, Du, Ming-Qing, Lucas, Peter C., McAllister-Lucas, Linda M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124150/
https://ncbi.nlm.nih.gov/pubmed/21273489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1198946
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