GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein

Antigen receptor–dependent (AgR-dependent) stimulation of the NF-κB transcription factor in lymphocytes is a required event during adaptive immune response, but dysregulated activation of this signaling pathway can lead to lymphoma. AgR stimulation promotes assembly of the CARMA1-BCL10-MALT1 complex...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: Cheng, Jing, Klei, Linda R., Hubel, Nathaniel E., Zhang, Ming, Schairer, Rebekka, Maurer, Lisa M., Klei, Hanna B., Kang, Heejae, Concel, Vincent J., Delekta, Phillip C., Dang, Eric V., Mintz, Michelle A., Baens, Mathijs, Cyster, Jason G., Parameswaran, Narayanan, Thome, Margot, Lucas, Peter C., McAllister-Lucas, Linda M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2020
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994119/
https://ncbi.nlm.nih.gov/pubmed/31961340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97040
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