Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor

BACE1 is a transmembrane aspartic protease that cleaves various substrates and it is required for normal brain function. BACE1 expression is high during early development, but it is reduced in adulthood. Under conditions of stress and injury, BACE1 levels are increased; however, the underlying mecha...

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Bibliografske podrobnosti
izdano v:Mol Cell Neurosci
Main Authors: Saadipour, Khalil, Tiberi, Alexia, Lomardo, Sylvia, Grajales, Elena, Montroull, Laura, Mañucat-Tan, Noralyn B., LaFrancois, John, Cammer, Michael, Mathews, Paul M., Scharfman, Helen E., Liao, Francesca-Fang, Friedman, Wilma J., Zhou, Xin-Fu, Tesco, Giueseppina, Chao, Moses V.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6993608/
https://ncbi.nlm.nih.gov/pubmed/31422108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2019.103395
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