A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products

BACKGROUND: Melanoma is one of the most aggressive tumors with the remarkable characteristic of resistance to traditional chemotherapy and radiotherapy. Although targeted therapy and immunotherapy benefit advanced melanoma patient treatment, BRAFi (BRAF inhibitor) resistance and the lower response r...

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發表在:Cancer Cell Int
Main Authors: Li, Keke, Zhao, Shuang, Long, Jing, Su, Juan, Wu, Lisha, Tao, Juan, Zhou, Jianda, Zhang, JiangLin, Chen, Xiang, Peng, Cong
格式: Artigo
語言:Inglês
出版: BioMed Central 2020
主題:
Primary Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6993520/
https://ncbi.nlm.nih.gov/pubmed/32021565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-020-1114-5
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