The Influence of Glycans-Specific Bioconjugation on the FcγRI Binding and In vivo Performance of (89)Zr-DFO-Pertuzumab

Rationale: The overwhelming majority of radioimmunoconjugates are produced via random conjugation methods predicated on attaching bifunctional chelators to the lysines of antibodies. However, this approach inevitably produces poorly defined and heterogeneous immunoconjugates because antibodies have...

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Bibliographische Detailangaben
Veröffentlicht in:Theranostics
Hauptverfasser: Vivier, Delphine, Fung, Kimberly, Rodriguez, Cindy, Adumeau, Pierre, Ulaner, Gary A., Lewis, Jason S., Sharma, Sai Kiran, Zeglis, Brian M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6993239/
https://ncbi.nlm.nih.gov/pubmed/32042334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.39089
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