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Removal of Fc Glycans from [(89)Zr]Zr-DFO-Anti-CD8 Prevents Peripheral Depletion of CD8(+) T Cells

The N-linked biantennary glycans on the heavy chain of immunoglobulin G (IgG) antibodies (mAbs) are instrumental in the recognition of the Fc region by Fc-gamma receptors (FcγR). In the case of full-length mAb-based imaging tracers targeting immune cell populations, these Fc:FcγR interactions can po...

詳細記述

保存先:
書誌詳細
出版年:Mol Pharm
主要な著者: White, Jordan M., Keinänen, Outi M., Cook, Brendon E., Zeglis, Brian M., Gibson, Heather M., Viola, Nerissa T.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307332/
https://ncbi.nlm.nih.gov/pubmed/32330387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.0c00270
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