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p53 dynamics in single cells are temperature-sensitive

Cells need to preserve genome integrity despite varying cellular and physical states. p53, the guardian of the genome, plays a crucial role in the cellular response to DNA damage by triggering cell cycle arrest, apoptosis or senescence. Mutations in p53 or alterations in its regulatory network are m...

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Publicat a:Sci Rep
Autors principals: Jentsch, Marcel, Snyder, Petra, Sheng, Caibin, Cristiano, Elena, Loewer, Alexander
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6992775/
https://ncbi.nlm.nih.gov/pubmed/32001771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58267-1
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