Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice

Apoptosis inducing factor (AIF) has been shown to be a major contributor to neuron loss in the immature brain after hypoxia-ischemia (HI). Indeed, mice bearing a hypomorphic mutation causing reduced AIF expression are protected against neonatal HI. To further investigate the possible molecular mecha...

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Udgivet i:Cell Death Dis
Main Authors: Li, Tao, Li, Kenan, Zhang, Shan, Wang, Yafeng, Xu, Yiran, Cronin, Shane J. F., Sun, Yanyan, Zhang, Yaodong, Xie, Cuicui, Rodriguez, Juan, Zhou, Kai, Hagberg, Henrik, Mallard, Carina, Wang, Xiaoyang, Penninger, Josef M., Kroemer, Guido, Blomgren, Klas, Zhu, Changlian
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6992638/
https://ncbi.nlm.nih.gov/pubmed/32001673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2280-z
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