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Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

Mutations in Cu/Zn superoxide dismutase 1 (SOD1) associated with familial amyotrophic lateral sclerosis cause the protein to aggregate via a prion-like process in which soluble molecules are recruited to aggregates by conformational templating. These misfolded SOD1 proteins can propagate aggregation...

詳細記述

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書誌詳細
出版年:PLoS One
主要な著者: Crown, Anthony, McAlary, Luke, Fagerli, Eric, Brown, Hilda, Yerbury, Justin J., Galaleldeen, Ahmad, Cashman, Neil R., Borchelt, David R., Ayers, Jacob I.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6991973/
https://ncbi.nlm.nih.gov/pubmed/31999698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227655
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