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The effect of two selective A(1)‐receptor agonists and the bitopic ligand VCP746 on heart rate and regional vascular conductance in conscious rats

BACKGROUND AND PURPOSE: Adenosine is a local mediator that regulates physiological and pathological processes via activation of four GPCRs (A(1), A(2A), A(2B), and A(3)). We have investigated the effect of two A(1)‐receptor‐selective agonists and the novel A(1)‐receptor bitopic ligand VCP746 on the...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Cooper, Samantha L., March, Julie, Sabbatini, Andrea R., Hill, Stephen J., Jörg, Manuela, Scammells, Peter J., Woolard, Jeanette
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989947/
https://ncbi.nlm.nih.gov/pubmed/31596949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14870
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