Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model

Proton-sensing ovarian cancer G-protein coupled receptor (OGR1) plays an important role in pH homeostasis. Acidosis occurs at sites of intestinal inflammation and can induce endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), an evolutionary mechanism that enables cells to cop...

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Udgivet i:Sci Rep
Main Authors: Maeyashiki, Chiaki, Melhem, Hassan, Hering, Larissa, Baebler, Katharina, Cosin-Roger, Jesus, Schefer, Fabian, Weder, Bruce, Hausmann, Martin, Scharl, Michael, Rogler, Gerhard, de Vallière, Cheryl, Ruiz, Pedro A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989664/
https://ncbi.nlm.nih.gov/pubmed/31996710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57657-9
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