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Mutual population-shift driven antibody-peptide binding elucidated by molecular dynamics simulations

Antibody based bio-molecular drugs are an exciting, new avenue of drug development as an alternative to the more traditional small chemical compounds. However, the binding mechanism and the effect on the conformational ensembles of a therapeutic antibody to its peptide or protein antigen have not ye...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bekker, Gert-Jan, Fukuda, Ikuo, Higo, Junichi, Kamiya, Narutoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989527/
https://ncbi.nlm.nih.gov/pubmed/31996730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58320-z
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