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Simulation study on the disordered state of an Alzheimer's β amyloid peptide Aβ(12–36) in water consisting of random-structural, β-structural, and helical clusters

The monomeric Alzheimer's β amyloid peptide, Aβ, is known to adopt a disordered state in water at room temperature, and a circular dichroism (CD) spectroscopy experiment has provided the secondary-structure contents for the disordered state: 70% random, 25% β-structural, and 5% helical. We perf...

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Bibliografiske detaljer
Main Authors: Ikebe, Jinzen, Kamiya, Narutoshi, Ito, Jun-Ichi, Shindo, Heisaburo, Higo, Junichi
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203368/
https://ncbi.nlm.nih.gov/pubmed/17656579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062721907
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