PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1

The Hippo signaling pathway controls organ development and is also known, in cancer, to have a tumor suppressing role. Within the Hippo pathway, we here demonstrate, in human gliomas, a functional interaction of a transmembrane protein, prostate transmembrane protein, androgen induced 1 (PMEPA1) wit...

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Udgivet i:Oncogene
Main Authors: Ji, Jianxiong, Ding, Kaikai, Luo, Tao, Xu, Ran, Zhang, Xin, Huang, Bin, Chen, Anjing, Zhang, Di, Miletic, Hrvoje, Bjerkvig, Rolf, Thorsen, Frits, Wang, Jian, Li, Xingang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989403/
https://ncbi.nlm.nih.gov/pubmed/31605013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-1050-9
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