Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma
Abstract Dysregulated cholesterol metabolism is a hallmark of many cancers, including glioblastoma (GBM), but its role in disease progression is not well understood. Here, we identified cholesterol 24‐hydroxylase (CYP46A1), a brain‐specific enzyme responsible for the elimination of cholesterol throu...
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| Auteurs principaux: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Springer Nature
2019-11-01
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| Collection: | EMBO Molecular Medicine |
| Sujets: | |
| Accès en ligne: | https://doi.org/10.15252/emmm.201910924 |
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