Structure–Activity Relationship Study on Soticlestat Derivatives for the Discovery of CYP46A1 (CH24H) Inhibitors

Dravet syndrome (DS) and Lennox–Gastaut syndrome (LGS) are rare, severe developmental and epileptic encephalopathies with poor prognosis, and novel drugs are urgently needed to meet clinical needs. CYP46A1 (cholesterol 24-hydroxylase, CH24H) is mainly responsible for the metabolism of cholesterol to...

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Principais autores:	Xinwei Hu, Wenqian Huang, Xiaotong Lin, Hao Zhang, Yishu Huang, Jiang Wu, Guilong Zhao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-01-01
coleção:	Molecules
Assuntos:	CH24H CYP46A1 soticlestat structure-activity relationship Dravet syndrome Lennox-Gastaut syndrome
Acesso em linha:	https://www.mdpi.com/1420-3049/31/3/460
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