Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination

BACKGROUND: Resistance to adjuvant radiotherapy is a major cause of treatment failure in patients with glioblastoma (GBM). Autophagy inhibitors have been shown to enhance the efficacy of radiotherapy for certain solid tumors. However, current inhibitors do not penetrate the blood-brain-barrier (BBB)...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Zhang, Xin, Xu, Ran, Zhang, Chao, Xu, Yangyang, Han, Mingzhi, Huang, Bin, Chen, Anjing, Qiu, Chen, Thorsen, Frits, Prestegarden, Lars, Bjerkvig, Rolf, Wang, Jian, Li, Xingang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584019/
https://ncbi.nlm.nih.gov/pubmed/28870216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0588-z
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