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Introduction to in silico model for proarrhythmic risk assessment under the CiPA initiative

In 2005, the International Council for Harmonization (ICH) established cardiotoxicity assessment guidelines to identify the risk of Torsade de Pointes (TdP). It is focused on the blockade of the human ether-à-go-go-related gene (hERG) channel known to cause QT/QTc prolongation and the QT/QTc prolong...

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Pubblicato in:Transl Clin Pharmacol
Autori principali: Park, Jin-Sol, Jeon, Ji-Young, Yang, Ji-Ho, Kim, Min-Gul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Korean Society for Clinical Pharmacology and Therapeutics 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989268/
https://ncbi.nlm.nih.gov/pubmed/32055576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12793/tcp.2019.27.1.12
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