Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca(2+) Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites

The goal of this research consortium including Janssen, MSD, Ncardia, FNCR/LBR, and Health and Environmental Sciences Institute (HESI) was to evaluate the utility of an additional in vitro assay technology to detect potential drug-induced long QT and torsade de pointes (TdP) risk by monitoring cytos...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Lu, Hua Rong, Zeng, Haoyu, Kettenhofen, Ralf, Guo, Liang, Kopljar, Ivan, van Ammel, Karel, Tekle, Fetene, Teisman, Ard, Zhai, Jin, Clouse, Holly, Pierson, Jennifer, Furniss, Michael, Lagrutta, Armando, Sannajust, Frederick, Gallacher, David J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Emerging Technologies, Methods, and Models
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657578/
https://ncbi.nlm.nih.gov/pubmed/31020317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz102
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