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Introduction to in silico model for proarrhythmic risk assessment under the CiPA initiative
In 2005, the International Council for Harmonization (ICH) established cardiotoxicity assessment guidelines to identify the risk of Torsade de Pointes (TdP). It is focused on the blockade of the human ether-à-go-go-related gene (hERG) channel known to cause QT/QTc prolongation and the QT/QTc prolong...
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| 出版年: | Transl Clin Pharmacol |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Korean Society for Clinical Pharmacology and Therapeutics
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6989268/ https://ncbi.nlm.nih.gov/pubmed/32055576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12793/tcp.2019.27.1.12 |
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