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Effect of p53 activation through targeting MDM2/MDM4 heterodimer on T regulatory and effector cells in the peripheral blood of Type 1 diabetes patients

Various immunotherapies for the treatment of type 1 diabetes are currently under investigation. Some of these aim to rescue the remaining beta cells from autoimmune attack caused by the disease. Among the strategies employed, p53 has been envisaged as a possible target for immunomodulation. We studi...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Pellegrino, Marsha, Traversi, Gianandrea, Arena, Andrea, Cappa, Marco, Rosado, M. Manuela, Andreani, Marco, Delfino, Domenico V., Moretti, Fabiola, Fierabracci, Alessandra
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988923/
https://ncbi.nlm.nih.gov/pubmed/31995625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228296
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